KMID : 0043319950180020105
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Archives of Pharmacal Research 1995 Volume.18 No. 2 p.105 ~ p.112
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Potential Role of Ca on the Differentiation of Erythroid Progenitor Cells
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Cho In-Koo
Hur In-Hoe Lee Sang-Joon Kim Dong-Seop Ann Hyoung-Soo
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Abstract
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In ordedr to gain insight into the mechanisms byl which erythropoietin promotes erythropoiesis, effects of various inhibitors on the erythropoietin-propmoted differentiation of erythroid progenitor cells and on the erythroid progenitor cells and on the erythropoietin-promoted uptake in the progenitor cells were determined, and the relationship between the inhibitory activity of each inhibitor cells were determined, and he relationship between the inhibitory activity of each inhibitor toward the differentiation and channel blocker (varapamil), a chelator (EDTA) and a protein kinase C inhibitor (stauroporine). All of these agents inhibited both the erythropoietin-mediated differentiation of the erythroid progenitor cells, as determined by the incroporation of into heme, and uptake in a concentrtion dependent manner. In the cases of varapamil and EDTA, the half-miximal inhibitory concentration values for differentiation of the progenitor cells may be theconsequence of the inhibition of the uptake in a concentration dependent manner. In the cases of varapamil and EDTA, the half-miximal inhibitory concentration dependent manner. In the cases of verapamil and EDTA, the half-miximal inhibitory concentration values for differentiation of the progenitor cells may be the consequence of the inhibition of the uptake by the inhibitor. On the other hand, in the cases of genistein and stauroporine, the values for inhibition of differentitation were significantly different from that for inhibition of uptake. These results suggest that the mechanism of inhibition of differentiation by these two inhibitors in complex. However, taken all together, the above results support the proposition that uptake may play a role in the erythropoietin-mediated differentiation of erythoid progenitor cells.
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KEYWORD
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Erythropoietin, uptake, Erythroid progeitor cellss, Genistein, Verapamil, H7, Staurosorine, Erythropoiesis
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